online degrees

Molecular Imaging and Therapy Research Unit (MIT)

หน่วยวิจัยโมเลกุลาร์อิมเมจจิงแอนด์เทอราปี (ESPRel no. 2-0040-0101-1)
Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 50200, Thailand

At the Molecular Imaging and Therapy (MIT) research unit, our mission is to lead the frontier in the Discovery, Research, and Development of Molecules for Innovation in Imaging and Therapy. We are committed to advancing scientific knowledge and pioneering breakthroughs that redefine the landscape of molecular imaging and therapeutic interventions. Our dedicated team strives to unravel the complexities of non-communicable diseases, with a particular focus on cancer, diabetes, cerebrovascular disorders, and brain and neurodegenerative diseases.

We aim to revolutionize diagnostic imaging and therapeutic modalities through meticulous discovery processes, cutting-edge research methodologies, and the development of novel molecules. Our mission extends beyond traditional boundaries, incorporating the rich pharmacological potential of Thai plants, extracts, and purified polyphenols. By combining ancient botanical wisdom with modern medical science, we seek to enhance the efficacy of conventional chemotherapy and radiotherapy.

In our relentless pursuit of innovation, we actively design, synthesize, and develop molecular imaging probes and theranostic agents. These agents hold the promise of transforming not only how we diagnose diseases but also how we approach their treatment. Additionally, our commitment extends to synthesizing metal complexes, exemplified by creations like Iron-Quercetin, serving as cutting-edge MRI contrast agents and facilitating stem cell tracking for advanced therapeutic applications.

Through our unwavering dedication to Discovery, Research, and Development, the MIT research unit aspires to catalyze positive change in healthcare. We envision a future where our innovative molecules redefine standards, offering new hope and improved patient outcomes worldwide.
Head of Unit
Jiraporn Kantapan
Member
Nathupakorn Dechsupa
Master and PhD Student
PhD student: Ms.Chengli Wen
PhD student:Ms.Yuanxia Zou
PhD student:Mr.Jiangchun Li
PhD student:Ms.Jiyuan Yuan
MRS student: Ms. Phattarawadee Innuan
Graduated Student
Dr.Guoqiang Yang (Ph.D.)
Mr.Siwaphon Paksee (MRS)

Department of Radiology, Division of Radiation Oncology, Faculty of Medicine
Department of Chemistry, Faculty of Science
Department of Medical Technology, Faculty of Associated Medical Sciences
Blood Bank Section, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine
Department of Pharmaceutical Sciences, Faculty of Pharmacy

Functional Ingredients and Food Innovation Research Group,National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathum Thani

Department of Biomedical ScienceSchool of Health Science, Chiang Rai

Université de Franche-Comté, EFS, INSERM, UMR RIGHT, F-25000 Besançon
INSERM CIC-1431, CHU Besançon, F-25000 Besançon

Luzhou Key Laboratory of Human Microecology and Precision Diagnosis and Treatment, Luzhou
Department of Gastroenterology, Affiliated Hospital of Southwest Medical University, Luzhou
Research Center for Integrated Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou
Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou,
COLLABORATION:

National & International

Publication

eBook

  • Book Chapter

    Plum Mango (Bouea macrophylla): Compositional Profile and Usage in Cancer

  • Author:
    Kantapan, J., Dechsupa, N.
  • eBook:
    Ancient and Traditional Foods, Plants, Herbs and Spices Used in Cancer
  • Year (Page):
    2023 (217–232)

Article

ALL SEARCH IN PUBMED

2023

  • Original
    Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/syk signaling pathway.
  • Author:
    Yang G, Kantapan J, Mazhar M, Bai X, Zou Y, Wang H, Huang B, Yang S, Dechsupa N, Wang L
  • Journal:
    Stem Cell Res Ther.
  • Year; Volume: Page
    2023 May 15;14(1):131
  • Review
    Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage.
  • Author:
    Zou Y, Liao L, Dai J, Mazhar M, Yang G, Wang H, Dechsupa N, Wang L
  • Journal:
    Regen Ther.
  • Year; Volume: Page
    2023 Feb 18;22:181-190.
  • Review
    Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells.
  • Author:
    Yang G, Fan X, Liu Y, Jie P, Mazhar M, Liu Y, Dechsupa N, Wang L
  • Journal:
    Stem Cell Rev Rep.
  • Year; Volume: Page
    2023 Jul;19(5):1214-1231.
  • Original
    Pentagalloyl Glucose-Targeted Inhibition of P-Glycoprotein and Re-Sensitization of Multidrug-Resistant Leukemic Cells (K562/ADR) to Doxorubicin: In Silico and Functional Studies.
  • Author:
    Dechsupa N, Khamto N, Chawapun P, Siriphong S, Innuan P, Suwan A, Luangsuep T, Photilimthana N, Maita W, Thanacharttanatchaya R, Sangthong P, Meepowpan P, Udomtanakunchai C, Kantapan J
  • Journal:
    Pharmaceuticals (Basel).
  • Year; Volume: Page
    2023 Aug 22;16(9):1192.
  • Review
    Pentagalloyl Glucose: A Review of Anticancer Properties, Molecular Targets, Mechanisms of Action, Pharmacokinetics, and Safety Profile.
  • Author:
    Wen C, Dechsupa N, Yu Z, Zhang X, Liang S, Lei X, Xu T, Gao X, Hu Q, Innuan P, Kantapan J, Lü M
  • Journal:
    Molecules.
  • Year; Volume: Page
    2023 Jun 19;28(12):4856.

2019-2022

Mesenchymal Stem Cell Application and Its Therapeutic Mechanisms in Intracerebral Hemorrhage.
Yang G, Fan X, Mazhar M, Yang S, Xu H, Dechsupa N, Wang L. Front Cell Neurosci. 2022 Jun 13;16:898497. doi: 10.3389/fncel.2022.898497. eCollection 2022.PMID: 35769327 (Review)
Neuroinflammation of microglia polarization in intracerebral hemorrhage and its potential targets for intervention.
Yang G, Fan X, Mazhar M, Guo W, Zou Y, Dechsupa N, Wang L. Front Mol Neurosci. 2022 Oct 11;15:1013706. doi: 10.3389/fnmol.2022.1013706. eCollection 2022.PMID: 36304999 (Review)
Iron-Quercetin Complex Preconditioning of Human Peripheral Blood Mononuclear Cells Accelerates Angiogenic and Fibroblast Migration: Implications for Wound Healing.
Kantapan J, Anukul N, Leetrakool N, Rolin G, Vergote J, Dechsupa N. Int J Mol Sci. 2021 Aug 17;22(16):8851. doi: 10.3390/ijms22168851.PMID: 34445558
A radiosensitizer, gallotannin-rich extract from Bouea macrophylla seeds, inhibits radiation-induced epithelial-mesenchymal transition in breast cancer cells.
Kantapan J, Paksee S, Duangya A, Sangthong P, Roytrakul S, Krobthong S, Suttana W, Dechsupa N. BMC Complement Med Ther. 2021 Jul 3;21(1):189. doi: 10.1186/s12906-021-03363-6.PMID: 34217266
Gallotannin from Bouea macrophylla Seed Extract Suppresses Cancer Stem-like Cells and Radiosensitizes Head and Neck Cancer.
Kantapan J, Dechsupa N, Tippanya D, Nobnop W, Chitapanarux I. Int J Mol Sci. 2021 Aug 26;22(17):9253. doi: 10.3390/ijms22179253.PMID: 34502158
Pentagalloyl Glucose- and Ethyl Gallate-Rich Extract from Maprang Seeds Induce Apoptosis in MCF-7 Breast Cancer Cells through Mitochondria-Mediated Pathway.
Kantapan J, Paksee S, Chawapun P, Sangthong P, Dechsupa N. Evid Based Complement Alternat Med. 2020 Apr 21;2020:5686029. doi: 10.1155/2020/5686029. eCollection 2020.PMID: 32382295
Iron (III)-Quercetin Complex: Synthesis, Physicochemical Characterization, and MRI Cell Tracking toward Potential Applications in Regenerative Medicine.
Papan P, Kantapan J, Sangthong P, Meepowpan P, Dechsupa N. Contrast Media Mol Imaging. 2020 Dec 29;2020:8877862. doi: 10.1155/2020/8877862. eCollection 2020.PMID: 33456403
Maprang "Bouea macrophylla Griffith" seeds: proximate composition, HPLC fingerprint, and antioxidation, anticancer and antimicrobial properties of ethanolic seed extracts.
Dechsupa N, Kantapan J, Tungjai M, Intorasoot S. Heliyon. 2019 Jul 11;5(7):e02052. doi: 10.1016/j.heliyon.2019.e02052. eCollection 2019 Jul.PMID: 31338468

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